2015/12/24 上午10:24:28 星期四
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汪俊松

汪俊松

简历

  

汪俊松,男,19757月生,安徽无为人,博士,教授,德国洪堡学者,南京理工大学博士研究生导师,江苏省“333工程(第二层次)和教育部新世纪优秀人才国家自然科学基金、中国博士后科学基金评审专家。世界中医药学会联合会中药化学专业委员会、中药上市后再评价专业委员会理事。主持德国洪堡学者研究基金,国家自然科学基金青年、面上基金,教育部新世纪优秀人才, “重大新药创制”科技重大专项候选药物研究等项目,参与并获得省部级、国家级科技奖励成果共四项。

  

Emailwang.junsong@gmail.com

Google Scholar文章列表: http://scholar.google.com/citations?user=DalIGdAAAAAJ

  

学习与工作经历

19929-19967月,安徽中医学院中药系获得中药学学士学位;

19967-19998月,安徽省中药材公司质检员;

19999-20053月,于中科院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室进行研究并获得理学博士学位;

20059-20071月,于韩国生命工学研究院进行博士后研究。

20072-20082月,在世界著名的亚历山大洪堡基金会资助下作为洪堡学者在德国癌症研究中心开展研究工作;

20083-20131月,作为海外引进人才供职中国药科大学中药学院(直聘副教授)。

20132月至今,南京理工大学环境与生物工程学院教授。

  

研究方向

1.天然药物化学研究:天然产物活性成分的提取、分离、结构鉴定、修饰及生物活性研究。

2中药复方研究:根据中药复方多成分、多靶点、整体作用的特点,综合运用系统科学、计算科学、非线性科学等多学科交叉融合手段处理其化学组成信息和药效活性信息,探讨其生物效应的谱效关系,构建中药复方的质量标准和评价体系。

3.代谢组学新技术新方法以及应用研究:以NMRUPLC-QTOF-MS为主要测试手段,对生物体内内源性代谢物进行定量分析,结合模式识别和专家系统等计算分析方法寻找代谢物与生理病理变化的相对关系,探讨代谢组在药效评价、疾病诊断、环境毒理中的应用研究。

  

  

主要文章列表

1. Chen, T.T.; Sheng, J.Y.; Fu, Y.H.; Li, M.H.; Wang, J.S.*; Jia, A.Q.*, 1H NMR-Based Global Metabolic Studies of Pseudomonas aeruginosa upon Exposure of the Quorum Sensing Inhibitor Resveratrol. Journal of Proteome Research2017, 16 (2), 824-830.

2. Jiang, L.; Si, Z.H.; Li, M.H.; Zhao, H.; Fu, Y.H.; Xing, Y.X.; Hong, W.; Ruan, L.Y.; Li, P.M.; Wang, J.S.*, 1H NMR-based metabolomics study of liver damage induced by ginkgolic acid (15:1) in mice. Journal of Pharmaceutical and Biomedical Analysis2017, 136, 44-54.

3. Li, P.#; Liao S.T.#; Wang, J.S.*; Xu, D.Q.; Zhang, Q.#; Xu, D.Q.; Lv, Y.; Yang, M.H.; Kong, L.Y.*, Protection by Huang-Lian-Jie-Du decoction and its constituent herbs of lipopolysaccharide-induced acute kidney injury. FEBS Open Bio2017, 7(2), 221-236.

4.  Zhao, H.; Si, Z.H.; Li, M.H.; Jiang, L.; Fu, Y.H.; Xing, Y.X.; Hong, W.; Ruan, L.Y.; Li, P.M.; Wang, J.S.*, Pyrazinamide-induced hepatotoxicity and gender differences in rats as revealed by 1H NMR based metabolomics approach. Toxicology Research2017, 6, 17-29.

5. Zhang, Q.; Wang, J.S.*; Zhang, C.; Liao S.T.; Li, P.; Xu, D.Q.; Lv, Y.; Yang, M.H.; Kong, L.Y.*, The components of Huang-Lian-Jie-Du-Decoction act synergistically to exert protective effects in a rat ischemic stroke model.Oncotarget2016, 5, DOI: 10.18632/oncotarget.12645.

6. Li, P.#; Liao S.T.#; Wang, J.S.*; Xu, D.Q.; Zhang, Q.#; Yang, M.H.; Kong, L.Y.*, NMR metabolic profiling of lipopolysaccharide-induced mice sepsis and the treatment effects of berberine. RSC advances2016, 6, 47474-47485.

7. Liao S.T.#; Li, P.#; Wang, J.S.*; Zhang, Q.#; Xu, D.Q.; Yang, M.H.; Kong, L.Y.*, Protection of baicalin on lipopolysaccharide induced liver and kidney injury based on 1H NMR metabolomic profiling. Toxicology Research2016, 5, 1148-1159.

8. Li, M.H.; Xu, H.D.; Liu, Y.; Chen, T.; Jiang, L.; Fu, Y. H.; Wang, J.S.*, Multi-tissue metabolic responses of goldfish (Carassius auratis) exposed to glyphosate-based herbicide. Toxicology Research2016, 5, 1039 - 1052.

9. Chen, T.; Liu, Y.; Li, M.H.#; Xu, H. D.; Sheng, J.Y.#; Zhang, L.; Wang, J.S.*, Integrated 1H NMR-based metabolomics analysis of earthworm responses to sub-lethal Pb exposure. Environmental Chemistry2016, doi:10.1071/EN15192

10. Li, P.; Wei, D.D.; Wang, J.S. *; Yang, M.H.; Kong, L.Y. *, 1H NMR metabolomics to study the effects of diazepam on anisatin induced convulsive seizures. Journal of Pharmaceutical and Biomedical Analysis 2016,117, 184-194.

11. Zhang, Q.; Guo, P.P.; Wang, J.S. *; Yang, M.H.; Kong, L.Y. *, Gender-specific metabolic responses in focal cerebral ischemia of rats and Huang-Lian-Jie-Du decoction treatment. RSC Advances 2015, 5 (116), 95558-95575.

12. Lou, Y.H; Wang, J.S.*; Dong, G.; Guo, P.P.; Wei, D.D.; Xie, S.S.; Yang, M.H.; Kong, L.Y.*, The acute hepatotoxicity of tacrine explained by 1H NMR based metabolomic profiling. Toxicology Research2015,4, 1465-1478

13. Li, M.H.#; Ruan, L.Y.#; Liu, Y.; Xu, H. D.; Chen, T.; Fu, Y.H.; Jiang, L.; Wang, J.S.*, Insight into biological system responses in goldfish (Carassius auratus) to multiple doses of avermectin exposure by integrated 1H NMR-based metabolomics. Toxicology Research2015, 4, 1374–1388.

14. Li, P.C.; Tao, J.; Wei, D.D.; Yang, X.; Lu, Z.G.; Deng, X.H.; Cheng, Y.; Gu, J.B.; Yang, X.J.; Wang, Z.J., Lu, Q.,* Wang, J.S.*, Yin, C.J., Serum metabolomic analysis of human upper urinary tract urothelial carcinoma. Tumor Biology2015, 36(19): 7531-7537.

15. Wei, D.D.#; Liao S.T.#; Wang, J.S.*; Yang, M.H.; Kong, L.Y.*, Cholestatic liver injury model of bile duct ligation and the protection of Huang-Lian-Jie-Du decoction by NMR metabolomic profiling. RSC advances2015, 5, 66200–66211.

16. Liu, Y.; Chen, T.; Li, M.H.; Xu, H.D.; Jia, A.Q.; Zhang, J.F.; Wang, J.S.*, 1H NMR based metabolomics approach to study the toxic effects of dichlorvos on goldfish (Carassius auratus). Chemosphere2015, 138, 537-545.

17. Dong, G.#; Wei, D.D.#; Wang, J.S.*; Guo, P.P; Li, M.H.; Yang, M.H.; Kong, L.Y.*, Study of the cardiotoxicity of Venenum Bufonis in rats using an 1H NMR-based metabolomics approach. Plos one2015, 10(3): e0119515.

18. Xiong, Y.Y. #*; Wang, J.S.#; Yu, H.; Zhang, X.L.; Miao, C.G, Anti-asthma potential of crocin and its effect on MAPK signaling pathway in a murine model of allergic airway disease. Immunopharmacology and Immunotoxicology2015 ,37(3), 236-243.

19. Guo, P.P.#; Wei, D.D. #; Wang, J.S.*; Dong, G.; Zhang, Q; Yang, M.H.; Kong, L.Y.*, Chronic toxicity of crude ricinine in rats assessed by 1H NMR metabolomics analysis. RSC advances2015, 5, 27018-27028.

20. Xu, H.D.; Wang, J.S.*; Li, M.H.; Liu, Y.; Chen, T.; Jia, A.Q.*, 1H NMR based metabolomics approach to study the toxic effects of herbicide butachlor on goldfish (Carassius auratus). Aquatic Toxicology 2015, 159, 69-80.

21. Dong G.; Wang, J.S.*; Guo, P.P; Wei D.D.; Yang, M.H.; Kong, L.Y.*, Toxicity assessment of Arisaematis Rhizoma in rats by a 1H NMR-based metabolomics approach.Molecular BioSystems2015 ,11(2), 407-417.

22. Wei, D.D.; Wang, J.S.*; Li, M.H.; Guo, P.P.; Dong, G.; Yang, M.H.; Kong, L.Y.*, A pilot study of the onset of hepatic encephalopathy (OHE) in mice induced by thioacetamide and the protective effect of taurine by holistic metabolic characterization. Metabolomics2015, 11 (3), 559-570.

23. Lu, Z.G.; Li, M.H.#; Wang, J.S.*; Wei, D.D.; Liu, Q.W.; Kong, L.Y.*, 1H NMR-based metabolomics study on a goldfish model of Parkinson’s disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Chemico-Biological Interactions2014, 223(5), 18-26.

24. Xiong, Y.Y. #*; Wang, J.S. #; Yu, H.; Zhang, X.L.; Miao, C.G.; Ma, S.T., The effects of nodakenin on airway inflammation, hyper-responsiveness and remodeling in a murine model of allergic asthma. Immunopharmacology and Immunotoxicology2014, 36(5), 341-348.

25. Wei, D.D.#; Dong, G.#; Guo, P.P.; Wang, J.S.*; Li, M.H.; Yang, M.H.; Kong, L.Y.*, A bird's eye view of anisatin induced convulsive seizures in brain by a 1H NMR based metabolic approach. Molecular BioSystems2014,10, 2923-2934.

26. Guo, P.P.; J. Wang, J.S.*; Dong G.; Wei D.D.; Li, M.H.; Yang, M.H.; Kong, L.Y.*, NMR-based metabolomics approach to study the chronic toxicity of crude ricin from castor bean kernels on rats. Molecular BioSystems2014, 10, 2426-2440.

27. Li, X.; Jia, Y.W.; Wang, J.S.*; Wang, Kelvin;Yang, M.H.; Kong, L.Y.*, 1H nuclear magnetic resonance-based metabolomics reveals sex-specific metabolic changes of gastrodin intervention in rats. Asian Pacific Journal of Tropical Medicine 2014, 7 (10), 811-818.

28. Lu, Z.G.#; Li, M.H.#; Wang, J.S.*; Wei, D.D.; Liu, Q.W.; Kong, L.Y.*, Developmental toxicity and neurotoxicity of two matrine-type alkaloids, matrine and sophocarpine, in zebrafish (Danio rerio) embryos/larvae. Reproductive Toxicology 2014, 47 (0), 33-41.

29. Wei D.D., Wang J.S.*, Wang P.R., Li, M.H.; Yang, M.H.; Kong, L.Y.*. Toxic effects of chronic low-dose exposure of thioacetamide on rats based on NMR metabolic profiling. Journal of Pharmaceutical and Biomedical Analysis2014, 98, 334-338

30. Li, M.H.; Wang, J.S.*; Lu, Z.G.; Wei, D.D.; Yang, M.H.; Kong, L.Y.*, NMR-based metabolomics approach to study the toxicity of lambda-cyhalothrin to goldfish (Carassius auratus). Aquatic Toxicology 2014, 146, 82-92.

31. Wang, P.R.; Wang, J.S.*; Yang, M.H.; Kong, L.Y.*, Neuroprotective effects of Huang-Lian-Jie-Du-Decoction on ischemic stroke rats revealed by 1H NMR metabolomics approach. Journal of Pharmaceutical and Biomedical Analysis2014, 88, 106-116.

32. Wang, P.R.; Wang, J.S.*; Zhang, C.; Song, X.F.; Tian N.; Kong, L.Y.*, Huang-Lian-Jie-Du-Decotion induced protective autophagy against the injury of cerebral ischemia/reperfusion via MAPK-mTOR signaling pathway. Journal of Ethnopharmacology2013, 149 (1), 270-280.

33. Yin, P.J.#; Wang, J.S.#; Wei, D.D.; Zhang, Y.; Wang, P.R.; Wang, X.B.; Kong, L.Y.*, Simonols A and B, two novel sesqui-neolignans from the fruits of Illicium simonsii. Fitoterapia2013, 88, 31-37.

34. Zhang, Y.; Wang, J.S.*; Wei, D.D.; Gu, Y.C.; Wang, X.B.; Kong, L.Y.*, Bioactive Terpenoids from the Fruits of Aphanamixis grandifolia. Journal of Natural Products2013, 76 (6), 1191-1195.

35. Tian, N.; Wang, J.S.*; Wang, P.R; Song, X.F.; Yang, M.H.; Kong, L.Y.*, NMR-based metabonomic study of Chinese medicine Gegen Qinlian Decoction as an effective treatment for type 2 diabetes in rats. Metabolomics2013, 9 (6), 1228-1242.

36. Song, X.F.; Wang, J.S.*; Wang, P.R.; Tian N.; Yang, M.H., Kong, L.Y.*, 1H NMR-based metabolomics approach to evaluate the effect of Xue-Fu-Zhu-Yu decoction on hyperlipidemia rats induced by high-fat diet, Journal of Pharmaceutical and Biomedical Analysis2013, 78-79, 202-210.

37. Wang, J.S.; Zhou J.; Kong, L.Y.*, Three new germacrane-type sesquiterpene stereoisomers from the flowers of Chrysanthemum indicum. Fitoterapia2012, 83 (8), 1675-1679.

38. Zhang, M.#; Wang, J.S.#; Wang, P.R.; Oyama, M.; Luo, J.; Ito, T.; Iinuma, M.*; Kong, L.Y.*, Sesquiterpenes from the aerial part of Chloranthus japonicus and their cytotoxicities. Fitoterapia2012, 83 (8), 1604-1609.

39. Xiong, Y.Y.#; Wang, J.S.#; Wu, F.H.; Li, J.; Kong, L.Y.*, The effects of (±)-Praeruptorin A on airway inflammation, remodeling and transforming growth factor-β1/Smad signaling pathway in a murine model of allergic asthma. International Immunopharmacology 2012, 14 (4), 392-400.

40. Xiong, Y.Y.#; Wang, J.S.#; Wu, F.H.; Li, J.; Zhou, L.F.; Kong, L.Y.*, Effects of (±)-praeruptorin A on airway inflammation, airway hyperresponsiveness and NF-κB signaling pathway in a mouse model of allergic airway disease. European Journal of Pharmacology2012, 683 (1-3), 316-324.

41. Guo, C.; Wang, J.S.*; Zhang, Y.; Yang, L.; Wang, P.R.; Kong, L.Y.*, Relationship of chemical structure to in vitro anti-inflammatory activity of tirucallane triterpenoids from the stem barks of Aphanamixis grandifolia. Chemical & Pharmaceutical Bulletin2012, 60 (8), 1003-1010.

42. Wang, J.S.#; Zhang, Y.#; Wang, X.B.; Kong, L.Y.*, Aphanalides A-H, ring A-seco limonoids from the fruits of Aphanamixispolystachya. Tetrahedron2012, 68 (21), 3963-3971.

43. Wang, J.S.; Zhang, Y.; Wang, X.B.; Wei, D.D.; Luo, J.; Luo, J.G.; Yang, M.H.; Yao, H.Q.; Sun, H.B.; Kong, L.Y.*, A pair of tirucallane C27-triterpenoid cyclopentenone epimers from the stem barks of Aphanamixis grandifolia. Tetrahedron Letters2012, 53 (14), 1705-1709.

44. Wei, D.D.; Wang, J.S.*; Zhang, Y.; Kong, L.Y., A new phenylpropanoid glycoside from the fruits of Illicium simonsii. ChineseJournal of Natural Medicines 2012, 10 (1), 20-23.

45. Wei, D.D.; Wang, J.S.*; Kong, L.Y.*, Reversal effects of components from the fruits of Illicium simonsii on human adriamycin-resistant MCF-7 and 5-fluorouracil-resistant Bel7402 cells. Phytotherapy Research2012, 26 (4), 562-567.

46. Wang, J.S.; Zhang, Y.; Wei, D.D.; Wang, X.B.; Luo, J.; Kong, L.Y.*, Novel tirucallane-type triterpenoids from Aphanamixis grandifolia. Chemistry & Biodiversity2011, 8 (11), 2025-2034.

47. Yang, L.; Wei, D.D.; Chen, Z.; Wang, J.S.*; Kong, L.Y.*, Reversal effects of Traditional Chinese herbs on multidrug resistance in cancer cells. Natural Product Research, 2011, 25 (19), 1885-1889.

48. Yang, L.; Wei, D.D.; Chen, Z.; Wang, J.S.*; Kong, L.Y.*, Reversal of multidrug resistance in human breast cancer cells by Curcuma wenyujin and Chrysanthemum indicum. Phytomedicine2011, 18 (8-9), 710-718.

49. Wang, J.S.; Zhang, Y.; Luo, J.; Kong, L.Y.*, Complete 1H and 13C NMR data assignment of protolimonoids from the stem barks of Aphanamixis grandifolia. Magnetic Resonance in Chemistry2011, 49 (7), 450-457.