2015/12/24 上午10:24:28 星期四
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师资队伍

翁丹

副教授, 硕士生导师

邮箱:danweng@njust.edu.cn

  

教育背景

2007.9—2014.7    University of Massachusetts Medical School(美国麻州大学医学院)博士

2004.9—2007.6    南京大学生命科学学院,理学硕士

2000.9—2004.6    南京大学生命科学学院,理学学士

  

研究方向

天然免疫,免疫毒理,免疫代谢

  

主持项目

1.国家自然科学基金-面上项目:从PPARγ信号通路研究双酚A诱导免疫毒性的作用机制 (No.21677076)2017.1-2020.12,项目负责人。

2. 国家自然科学基金-青年基金:RIP1 在细菌诱导的炎症小体活化过程中的作用及机制研究 (No.31500698), 2016.1-2018.12项目负责人。

3.苏省自然科学基金-青年基金:细菌感染中受体相互作用蛋白1调控炎性小体的作用及分子机制 (No. BK 20150772)2015.7-2018.6,项目负责人。

  

  

学术论文

1. Dan Weng, Robyn Marty-Roix, Sandhya Ganesan, Megan K. Proulx, Gregory I. Vladimer, William J.Kaiser et al., Katherine A. Fitzgerald, Neal Silverman, Egil Lien*. Caspase-8 and RIP kinases are key regulators of bacteria-induced innate immune responses and cell death. Proc Natl Acad Sci USA, 2014, 111(20):7391-7396 (封面文章)

  

2. Xiujing Feng, Dan Weng, Feifei Zhou, Young D Owen, Haohan Qin, Jingfa Zhao, Yahong Huang, Jiajia Chen, Haijian Fu, Nanfei Yang, Dianhua Chen, Jianxin Li, Renxiang Tan, Pingping Shen*. Activation of PPARγ by a natural flavonoid modulator, apigenin ameliorates obesity-related inflammation via regulation of macrophage polarization, EbioMedicine, 2016, 9: 61-76.

  

3. Marty-Roix R, Vladimer GI, Pouliot K, Weng D, Buglione-Corbett R, West K, MacMicking JD, Chee JD, Wang S, Lu S, Lien E*. Identification of QS-21 as an Inflammasome-activating Molecular Component of Saponin Adjuvants, Journal of Biological Chemistry, 2016, 291(3):1123-1136.

  

4. Vladimer GI, Weng D, Paquette SW, Vanaja SK, Rathinam VA, Aune MH, Conlon JEBurbage JJ, Proulx MK, Liu Q, Reed G, Mecsas JC, Iwakura Y, Bertin J, Goguen JDFitzgerald KA, Lien E*. The NLRP12 inflammasome recognizes Yersinia pestis. Immunity, 2012, 37(1):96-107

  

5. Vladimer GI, Marty-Roix R, Ghosh S, Weng D, Lien E*. Inflammasomes and host defenses against bacterial infections. Current Opinion in Microbiology, 2013, 16(1):23-31

  

6. Dan Weng, Yan Lu, Yinna Wei, Ying Liu, Pingping Shen*. The role of ROS in Microcystin-LR-induced hepatocyte apoptosis and liver injury in mice. Toxicology, 2007,232:15-23.

  

7. Y Wei, D Weng, F Li, X Zou, Do Young, J Ji, P Shen*. Involvement of JNK regulation in oxidative stress-mediated murine liver injury by microcystin-LR. Apoptosis, 2008, 13(8): 1031-1042  (备注:Y WeiD Weng同为第一作者)