2015/12/24 上午10:24:28 星期四
特别鸣谢86361班校友捐赠制作环境与生物工程学院网站
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包晓峰

包晓峰

Email: baoxiaofeng@mail.njust.edu.cn


主要研究领域

1:轮烷药物载体

2:分子影像与探针


个人简介 

  

  男,19767月,理学博士,南京理工大学生物工程系,博士生导师,副教授。1999年毕业于南京理工大学化工学院2007年获美国辛辛那提大学有机化学博士学位;曾获美国国立卫生研究院NIH Postdoctoral Fellowship (2008-2010)美国俄亥俄州立大学Postdoctoral Fellowship (2007-2008)美国辛辛那提大学 University Fellowship (2003-2007)美国依利诺依大学芝加哥分校University Fellowship (2002-2003);近年来以第一作者/通讯作者在本领域主流SCI期刊Journal of the American Chemical SocietyJournal of Medicinal ChemistryJournal of Organic Chemistry等发表研究论文30篇,SCI 论文他引次数300多次;授权专利8, 获国家自然科学基金面上项目(2013-2017),江苏省自然科学基金面上项目(2011-2013)等资助;主要从事轮烷药物载体、荧光分子探针、PET造影剂的研究与开发。

  

教育经历

  

20038-20076月,美国辛辛那提大学化学系,有机化学,博士

20028-20038月,美国伊利诺伊大学芝加哥分校化工系,博士研究生

19999-20027月,南京理工大学化工学院,生物化工,硕士

19959-19997月,南京理工大学化工学院,高分子化工,学士

  

工作经历

20136-至今,南京理工大学,生物工程系,博士生导师,副教授

20112-至今,南京理工大学,生物工程系,硕士生导师,副教授

20083-20107月,美国国立卫生研究院,博士后研究员

20076-20083月,美国俄亥俄州立大学医学研究中心,博士后

20038-20073月,美国辛辛那提大学化学系,研究助理

20028-20038月,美国依利诺大学芝加哥分校,助教

  

资助项目

江苏省自然科学基金面上项目(2011-2013,项目负责人,8万,结题优秀)。

江苏省海外归国人员择优资助(2011-2012,项目负责人,8万)。

南京理工大学自主科研项目(2011-2014,项目负责人,45万)。

国家自然科学基金面上项目(2014-2017,项目负责人,70万)。

教育部博士点基金新教师类(2014-2015,项目负责人,4万)。

  

代表性论文


2017

  1. Tong Zhou, Xiangxue Chen, Qinghan Hua, Wu Lei, Qingli Hao, Baojing Zhou, Chang Su, Xiaofeng Bao*, Synthesis and evaluation of a new furfuran-based rhodamine B fluorescent chemosensor for selective detection of Fe3+ and its application in living-cell imaging, Sensors and Actuators B: Chemicals, 2017,253, 292-301.

  2. Hailang Chen, Baojing Zhou, Renlong Ye, Jing Zhu*, Xiaofeng Bao*, Synthesis and evaluation of a new fluorescein and rhodamine B-based chemosensor for highly sensitive and selective detection of cysteine over other amino acids and its application in living cell imaging, Sensors and Actuators B: Chemicals,2017,251,481-489.

  3. Hai Shu, Xiaolei Wu, Baojing Zhou, Yingbin Han, Mingjie Jin, Jing Zhu* and Xiaofeng Bao*,Synthesis and evaluation of a novel fluorescent chemosensor for glutathione based on a rhodamine B and N-[4-(carbonyl) phenyl] maleimide conjugate and its application in living cell imaging, Dyes and Pigments, 2017, 136, 535-542.

  4. Hailang Chen, XiaofengBao*, Hai Shu, Baojing Zhou, Renlong Yeand Jing Zhu*, Synthesis and evaluation of a novel rhodamine B-based 'off-on' fluorescent chemosensor for the selective determination of Fe3+ ions,Sensors and Actuators B: Chemicals,2017,242,921-931.

  5. 2016

  6. Xiaolei Wu, Hai Shu, Baojing Zhou, Yougliang Geng, Xiaofeng Bao*, Jing Zhu*,Design and Synthesis of a New Rhodamine B-Based Fluorescent Probe for Selective Detection of Glutathione and Its Application for Live Cell Imaging, Sensors and Actuators B: Chemicals, 237, 431-442.

  7. Xiaofeng Bao*, Jiaxin Shi, Jing Zhu, Xinlong Wang*, A novel sensitive and selective nanocomposite sensor for Doxorubicin based on Graphene Oxide and fluorescent [2]Rotaxane, Sensors and Actuators B: Chemicals,237, 380-386.

  8. 沈薇*, 王林, 陈敏, 吴旻, 包晓峰*, 芘基探针PYPA的合成及在PPi作用下对Zn2+的高效识别, 中国有机化学, Chin. J. Org. Chem. 2016, 36, 2204-2211.

  9. Xiaofeng Bao*, Xiaolei Wu, Hai Shu, Qianshen Cao, and Jing Zhu* Design and synthesis of a new selective fluorescent chemical sensor for Cu2+ based on a Pyrrole moiety and a Fluorescein conjugate,Tetrahedron Letters, 57 (8), 942-948.

  10. Wei Shen, Lin Wang, Min Wu, Xiaofeng Bao*, A fluorescein derivative FLTC as a chemosensor for Hg2+ and Ag+ and its application in living-cell imaging, Inorganic Chemistry Communications, 2016, 70, 107-110.

2015

  1. Bao, X.*; Cao, Q.; Xu, Y.; Nie, X.; Zhou B.; Zhu, J.*Design and synthesis of a novel chromium(III) selective fluorescent chemosensor bearing a thiodiacetamide moiety and two rhodamine B fluorophores, Sensors and Actuators B, Chemicals, 2015221, 930-939.

  2. Bao, X.*; Cao, X.; Nie X.; Zhou, B., Zhang, L.*; Liao, H.; Pang, T,  A new selective fluorescent chemical sensor for Fe3+ based on rhodamine B and a 1,4,7,10-tetraoxa-13-azacyclopentadecane conjugate and its imaging in living cellsSensors and Actuators B,  Chemicals 2015208, 54-56.

  3. Shi, J.; Wang, X., Nie, X., Zhou, B., Zhu, J.*; Pang T.*Bao X.*, Synthesis and evaluation of a novel Rhodamine B pyrene [2]rotaxane as an intracellular delivery agent for doxorubicin, Organic & Biomolecular Chemistry, 2015 (13), 7517-7529.

  4. Bao, X.*; Cao, Q.; Xu, Y.; Gao, Y.; Xu, Y.; Nie, X.; Zhou B.; Pang, T.; Zhu, J.*, Synthesis and evaluation of a new Rhodamine B and Di(2-picolyl) amine conjugate as a highly sensitive and selective chemosensor for Al3+ and its application in living-cell imaging. Bioorganic Medicinal Chemistry, 2015, 23(4), 694-702.

  5. Shi, J.; Cao, X.; Wang, X., Nie, X., Zhou, B., Bao, X.*Zhu, J.*, A novel switchable [2]rotaxane driven by light energy with Rhodamine B as a stopper, Tetrahedron, 2015,71 (24), 4116-4123.

  6. Hailang Chen, Xiaofeng Bao*, Feng Li, Baojing Zhou, Renlong Ye and Jing Zhu*Synthesis of a new highly sensitive near-infrared fluorescentIridium(III) probe and its application for the highly selectivedetection of glutathione, RSC Adv., 2015,5, 85095-85104.


2014

  1. Bao, X.*; Jin, Y.; Liu, X.; Liao, H.; Zhang, L.; Pang, T., Synthesis and biological evaluation of XB-1 analogues as novel histamine H-3 receptor antagonists and Neuroprotective agents. RSC Advances, 2014, 4 (13), 6761-6775.

  2. Liu, D.; Pang, T.; Ma, K.; Jiang, W.; Bao, X.*, A new highly sensitive and selective fluorescence chemosensor for Cr3+ based on rhodamine B and a 4,13-diaza-18-crown 6-ether conjugate. RSC Advances 2014, 4 (5), 2563-2567.

  3. Bao, X.*; Shi, J.; Nie, X.; Zhou, B.; Wang, X.; Zhang, L.*; Liao, H.; Pang, T., A new Rhodamine B-based 'on-off' chemical sensor with high selectivity and sensitivity toward Fe3+ and its imaging in living cells. Bioorganic & Medicinal Chemistry, 2014, 22 (17), 4826-4835.

  4. Xiaofeng Bao*, Xiaowei Cao, Xuemei Nie, Yanyan Jin and Baojing Zhou, RBAP, a Rhodamine B-based Derivative: Synthesis, Crystal Structure Analysis, Molecular Simulation, and its Application as a Selective Fluorescent Chemical Sensor for Sn2+Molecules, 2014, 19(6), 7817-7831.


2013

  1. Bao, X.*; Liu, D.; Jin, Y.; Liu, X.; Jiang, W., Design and synthesis of a novel Rhodamine B 2 rotaxane. RSC Advances, 2013, 3 (19), 6783-6786.

  2. Xiaofeng Bao*, Xiaolu, LiuSynthesis of histamine subtype 3 receptor antagonists based on a Nonimidazole 2-Aminoethylbenzofuran for prospective molecular imaging radiotracersJournal of Labelled Compounds & Radiopharmaceuticals2013, 56, S268-S268. 

  3. Xiaofeng Bao*, Yanyan Jin, Synthesis of novel acyclic non-imidazole XB-1 analogues as precursors for H3 receptor PET radioligandsJournal of Labelled Compounds & Radiopharmaceuticals,2013, 56S267-268.

  

2012

  1. Bao, X.; Lu, S.; Liow, J.-S.; Zoghbi, S. S.; Jenko, K. J.; Clark, D. T.; Gladding, R. L.; Innis, R. B.; Pike, V. W.*, Radiosynthesis and Evaluation of an F-18-Labeled Positron Emission Tomography (PET) Radioligand for Brain Histamine Subtype-3 Receptors Based on a Nonimidazole 2-Aminoethylbenzofuran Chemotype. Journal of Medicinal Chemistry, 2012, 55 (5), 2406-15. 

  2. Bao, X.; Lu, S.; Liow, J.-S.; Morse, C. L.; Anderson, K. B.; Zoghbi, S. S.; Innis, R. B.; Pike, V. W.*, C-11 Rhodamine-123: Synthesis and biodistribution in rodents. Nuclear Medicine and Biology, 2012, 39 (8), 1128-1136. 

  3. Xiaofeng Bao*, Duliang Liu, Yanyan Jin and Yao YangA Facile Synthesis for Novel Loperamide Analogs as Potential μ Opioid Receptor Agonists. Molecules, 2012, 17, 14288-14297.

  

2006-2011

  

  1. Bao, X.; Isaacsohn, I.; Drew, A. F.; Smithrud, D. B.*, Determining the intracellular transport mechanism of a cleft- 2 rotaxane. Journal of the American Chemical Society 2006, 128 (37), 12229-12238.

  2. Bao, X.; Isaacsohn, I.; Drew, A. F.; Smithrud, D. B.*, Determining the binding and intracellular transporting abilities of a host- 3 rotaxane. Journal of Organic Chemistry 2007, 72 (11), 3988-4000. ( IF 4.8)

  3. Bao Xiaofeng; Lu Shuiyu; Liow Jeih-San; Victor W. Pike*, Radiolabeling and evaluation of [18F]XB-1 in monkey as a prospective histamine subtype 3 receptor PET radioligandJournal of Labelled Compounds & Radiopharmaceuticals2011,54 (1),S83-S83. 

  4. Bao Xiaofeng; Lu S.; Simeon F. G.; Victor W. Pike*; Synthesis of a prospective (18)f-labeled tracer for imaging p-glycoprotein function, Journal of Labelled Compounds & Radiopharmaceuticals; 2009, 52 ,S350-S350.

  5. Bao Xiaofeng.; Morse C. L.; Lu S.; Victor W. Pike*, Synthesis of [11C]Rhodamine-123 as a potential tracer for imaging p-glycoprotein functionJournal of Labelled Compounds & Radiopharmaceuticals2009,52, S427-S427.


授权专利

  1. 一种脑组胺H3受体放射性配体的前体及其制备方法;包晓峰,金艳艳,刘晓露,刘督亮,曹小伟;授权号:ZL 2013 1 0176094.3

  2. 一种基于罗丹明B的荧光传感器的制备及其应用包晓峰,曹小伟,金艳艳,刘督亮,史加新;授权号: ZL 2014 1 0110840.3

  3. 一种基于罗丹明B的铝离子荧光传感器的制备及其应用;包晓峰, 曹乾升, 曹小伟, 史加新; 授权号:ZL 2014 1 0342704.7

  4. 一种荧光化学传感器及其制备;包晓峰,刘督亮,金艳艳,曹小伟,陈晓燕;授权号: ZL 2013 1 0418372.1

  5. Al3+荧光传感器的合成方法及应用;包晓峰,曹乾升;曹小伟;史加新,授权号:ZL 2014 1 0217846.0

  6. 一种基于罗丹明BCr3+传感器的制备及应用;包晓峰,曹乾升,吴小磊,史加新,舒海; 授权号:ZL 2014 1 0736192.2

  7. 一种罗丹明B的荧光传感器制备及其应用;包晓峰;史加新,曹乾升,曹小伟,陈晓燕; 授权号:ZL 2014 1 0128983.7

  8. 一种基于罗丹明B的荧光传感器及制备;包晓峰,陈晓燕,曹乾升;曹小伟;授权号: ZL 2014 1 0637758.6